Charles Wesley Mathers was born in Lucknow, Ontario in 9 January 1968 to Irish immigrants, Christopher and Rachel (Graham) Mathers. In 1891 Mathers moved to Edmonton, Alberta to work at a photography studio. Mathers was one the the earliest photographer from Edmonton. In 1986 Mathers married Minnie Jane Magee and had one son.
Mathers photographed life in northern Canada during the turn of the century. In 1901 he accompanied William H. Connor, an independent trader from Edmonton to the mouth of the Mackenzie River and along the river routes of the Northwest Territories. Mathers documented his trip including photographing hunting and trading activities and later produced the souvenir album "The Far North" with photographs of his travels. Mathers is also known for photographs related to the Klondike Gold Rush.
Mather passed away in California in 1950.